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NAD+ Precursors vs NAD Regen: Unraveling the Truth About Longevity Supplements

June 07, 2023 4 min read

NAD Regen vs NAD Precursors

In the quest for health optimization and longevity, the molecule Nicotinamide Adenine Dinucleotide (NAD+) has emerged as a key player. This vital coenzyme plays a crucial role in numerous metabolic reactions in our bodies. However, as we age, our NAD+ levels naturally decline, leading to a surge of interest in NAD+ precursors and supplements designed to boost these levels.

One such supplement is NAD Regen, a product of BioStack, which promises to support energy production, cognitive function, and promote healthy aging. In this article, we'll delve into the science behind NAD+ precursors and NAD Regen, comparing their mechanisms of action, research support, and potential benefits.

Understanding NAD+ Precursors

NAD+ precursors, including Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR), have been proposed to combat aging and extend lifespan by raising NAD concentration at the tissue and cell levels. The theory is that by supplementing with these precursors, we can effectively raise our NAD+ levels, potentially reversing some aspects of aging and improving our overall health.

"NAD is a critical molecule for storing and transferring electrons and is involved in over 500 distinct metabolic reactions in the body." - Peter Attia MD

However, the evidence supporting the use of NAD+ precursors is still largely theoretical. The few studies investigating the effect of NMN and NR on circulating NAD levels have generated conflicting results. Despite their popularity, there's little solid evidence to back claims of their benefits.

Exploring NAD Regen

NAD Regen, by BioStack Labs, is a cutting-edge supplement designed to increase energy, enhance cognitive function, and slow down the aging process. Unlike other supplements that simply aim to boost NAD+ levels, NAD Regen takes a more comprehensive approach.

The supplement contains a unique blend of ingredients, including:

  • Niacinamide – 125mg
  • NAD3® (Wasabi Extract, Theacrine, Cuprous Niacin) – 311mg
  • Resveratrol 50% (Polygonum cuspidatum) - 200mg
  • Spermidine HCl (as Yüth™) – 5mg
  • Black Pepper Extract 95% Piperine (as BioPerine®) – 5mg

Each of these ingredients plays a unique role in supporting NAD+ levels and promoting overall health. For instance, NAD3® is designed to improve NAD+ status by supporting its synthesis and limiting its degradation. Let’s have a closer look at NAD3.

NAD3 is made out of Cuprous Niacin, Theacrine and Wasabi Japonica.

Niacin as we know is a NAD precursor, it being Cuprous aka Copper means it also allows for it to be a critical cofactor for several mitochondrial reactions in cell culture. Niacinamide was added to the NAD Regen formula as Niacin alone was not strong enough as a precursor itself. 

Theacrine, often compared to caffeine without the negative side effects, has various benefits; however the focus here is its inflammation reduction skills. 

This is an important component to consider when it comes to NAD levels. One of the main reasons we find less NAD as we age is due to age-related chronic low level inflammation using (or rather sucking up) NAD molecules to keep inflammation down. 

Furthermore there is Wasabi Japonica (6-MSITC  is the bioactive substance) which has shown to upregulate SIRT1 protein levels (SIRT1 is primarily known for its role in regulating cellular metabolism, and it has been implicated in a number of cellular processes, including DNA repair, apoptosis, and inflammation. 

The power behind NAD3 is the apparent complementary action among all three ingredients. Especially when it comes to greater LDL cholesterol reduction.

Resveratrol helps increase NAMPT, a key enzyme that plays a role in the production and recycling of NAD+. Spermidine works to clean up "zombie cells", lowering inflammation and helping NAD3® do its work.

Comparing NAD+ Precursors and NAD Regen

When comparing NAD+ precursors and NAD Regen, it's important to consider both their mechanisms of action and the research supporting each.

NAD+ precursors, such as NMN and NR, are proposed to raise NAD+ levels by providing the body with the raw materials it needs to produce more NAD+. However, the evidence supporting their effectiveness is still largely theoretical and based on animal studies.

Precursors can also potentially deplete the methyl pool by using too much methylation capacity. Put simply, adding stress to systems in your body that you’re trying to destress by consuming the precursor in the first place. 

Optimal methylation is necessary for homocysteine metabolism/clearance of neurotransmitters, antioxidant and detox function. NAD3 may be the safest & most effective strategy to optimize NAD+ status without stressing the body's methylation capacity.

Using NAD3 in the NAD Regen formula makes it a more comprehensive approach. Rather than simply providing the body with more raw materials to produce NAD+, it works to support the body's natural NAD+ production and recycling processes, while also addressing other aspects of health and aging (and without using too much methylation capacity.) 

NAD+ Precursors

NAD Regen

Mechanism of Action

Provides raw materials for NAD+ production

Supports NAD+ synthesis and recycling, and addresses other aspects of health

Research Support

Mostly theoretical and based on animal studies

Backed by clinical research and studies

Unique Features

Simple and straightforward approach

Comprehensive approach with a blend of ingredients


The quest for longevity and health optimization has led to a surge of interest in NAD+ and ways to boost its levels in the body. While NAD+ precursors such as NMN and NR offer a straightforward approach, supplements like NAD Regen provide a more comprehensive solution.

However, it's important to remember that while these supplements can support our health, they are not a substitute for a healthy lifestyle. Regular exercise, a balanced diet, and adequate sleep are still the cornerstones of good health and longevity.

Before starting any new supplement regimen, it's always a good idea to consult with a healthcare professional. They can provide personalized advice based on your individual health needs and goals.

"The greatest wealth is health." - Virgil

Remember, the journey to health and longevity is a marathon, not a sprint. So take it one step at a time, and enjoy the process.


  1. NMN and Exercise Performance - Peter Attia MD
  2. NAD Regen - BioStack Labs
  3. Effects of NAD3® on Hallmarks of Aging and Clinical Endpoints of Health in Middle Aged Adults
  4. A Theacrine-Based Supplement Increases Cellular NAD+Levels and Affects Biomarkers Related to Sirtuin Activity in C2C12 Muscle Cells In Vitro